On 13 May 2022, the African Commission on Human and Peoples’ Rights (ACHPR) adopted the Guidelines on Enforced Disappearances in Africa (EDA Guidelines) at its 71st Ordinary Session in Banjul, The Gambia. This Q&A addresses the key concepts and terminology, the main contexts in which enforced disappearance (ED) happens in Africa, the rights infringed upon by this crime, the main obstacles faced by victims seeking justice, and the States’ obligations.