This practice note explains what holistic strategic litigation is, and how to do it in the context of enforced disappearances in Africa. It makes suggestions based on academic commentaries, research reports, and practical experience. It will be useful for those new to strategic litigation, to find out more about it, and also for more experienced practitioners, to encourage reflection on how they do it. REDRESS would like to thank the Matrix Causes Fund and the United Nations Voluntary Fund for Victims of Torture for their generous support to this project.